Staff Profile: Philip J McCall
Philip J McCall MSc PhD FRES
Appointment: Everett-Dutton Reader in Medical Entomology
I graduated in Biology (BSc, Cork, Ireland) and Animal Parasitology (MSc, Bangor, Wales) and received a PhD from Liverpool University/Liverpool School of Tropical Medicine for studies on the transmission of bovine Onchocerca sp. After a number of research posts, including with the Onchocerciasis Control Programme in West Africa, I spent time under a Wellcome Trust Fellowship at the Center for Medical, Agricultural & Veterinary Entomology (CMAVE), Gainesville, Florida, USA investigating resource location behaviour, and in the Netherlands and UK, before returning to LSTM in 1998.
Vector-borne diseases are a major barrier to development in many countries worldwide. My research aims to understand the biology and behaviour of the arthropod vectors, how this influences disease epidemiology, and how that knowledge can assist development of appropriate interventions. As education and capacity building in disease-endemic countries are essential to ensure that research delivers practical outcomes, training is integral to research projects wherever possible.
Ecology & epidemiology
Understanding the ecology and behaviour of the different disease vectors is fundamental to understanding the epidemiology of these diseases. My studies variously investigate competition, life histories, behaviour and natural history of vector populations and how they inform potential vector control strategies for preventing malaria (in Malawi, Ghana, Tanzania; the Tihama coastal plain and southern highlands of the western Arabian Peninsula) and dengue (Venezuela); chemical and behavioural ecology of host and oviposition site choice (the dengue vector Aedes aegypti and the African malaria vectors); natural history of the soft tick vectors and the epidemiology of tick-borne relapsing fever (TBRF) in east Africa (Tanzania).
Prevention and control Most of these diseases are preventable but effective methods, suitable for widespread use in a range of local contexts, are not always available. Part of my research aims to develop and evaluate appropriate intervention tools for the prevention and control of vector-borne disease, often using insight gained from the studies described above. Numerous studies and randomised controlled trials have include projects on dengue control in Venezuela, Thailand and Mexico primarily (and in a number of other countries in SE Asia and Latin America), malaria control in urban Ghana, and the control of TBRF in central Tanzania; the elimination of onchocerciasis vectors from the island of Bioko, Equatorial Guinea (completed) and from Yemen (proposed/ advocated).
Work is supported by The Wellcome Trust, WHO/TDR and the Sir Halley Stewart Trust
Committees, technical advisory panels, etc
World Health Organisation/ Special Programme for Research and Training in Tropical Diseases (TDR)
- Member of the WHO/TDR Disease-Specific Reference Group (DRG) on Dengue and Other Emerging Viral Diseases of Public Health Importance (from 2008)
- Member of the WHO/TDR Scientific Working Group/ Expert Committee on Dengue Research, (2006). WHO Geneva.
- Member of the Product Development Team for the WHO/ TDR/ IDRC Research Initiative on Eco-Bio-Social Research on Dengue in Asia (2006), WHO Geneva.
Che-Mendoza, A., Guillermo-May, G., Herrera-Bojorquez, J., Barrera-Perez, M., Dzul-Manzanilla, F., Gutierrez-Castro, C., Arredondo-Jimenez, J. I., Sanchez-Tejeda, G., Vazquez-Prokopec, G., Ranson, Hilary, Lenhart, A., Sommerfeld, J., McCall, Philip, Kroeger, A. and Manrique-Saide, P. (2015) 'Long-lasting insecticide-treated house screens and targeted treatment of productive breeding-sites for dengue vector control in Acapulco, Mexico'. Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol 109, Issue 2, pp. 106-115.
Manrique-Saide, Pablo, Che-Mendoza, Azael, Barrera-Perez, Mario, Guillermo-May, Guillermo, Herrera-Bojorquez, Josue, Dzul-Manzanilla, Felipe, Gutierrez-Castro, Cipriano, Lenhart, Audrey, Vazquez-Prokopec, Gonzalo, Sommerfeld, Johannes, McCall, Philip, Kroeger, Axel and Arredondo-Jimenez, Juan I. (2015) 'Use of Insecticide-Treated House Screens to Reduce Infestations of Dengue Virus Vectors, Mexico'. Emerging Infectious Diseases, Vol 21, Issue 2, pp. 308-311.
Coleman, Michael, Al-Zahrani, Mohammed H., Coleman, Marlize, Hemingway, Janet, Omar, Abdiasiis, Stanton, Michelle, Thomsen, Edward, Alsheikh, Adel A., Alhakeem, Raafat F., McCall, Philip, Rabeeah, Abdullah A. Al and Memish, Ziad A. (2014) 'A Country on the Verge of Malaria Elimination – The Kingdom of Saudi Arabia'. PLoS ONE, Vol 9, Issue 9, e105980.
Manrique-Saide, P., Coleman, P., McCall, Philip, Lenhart, Audrey, Vazquez-Prokopec, G. and Davies, C. R. (2014) 'Multi-scale analysis of the associations among egg, larval and pupal surveys and the presence and abundance of adult femaleAedes aegypti(Stegomyia aegypti) in the city of Merida, Mexico'. Medical and Veterinary Entomology, Vol 28, Issue 3, pp. 264-272.
Reiner, R. C., Stoddard, S. T., Forshey, B. M., King, A. A., Ellis, A. M., Lloyd, A. L., Long, K. C., Rocha, C., Vilcarromero, S., Astete, H., Bazan, I., Lenhart, Audrey, Vazquez-Prokopec, G. M., Paz-Soldan, V. A., McCall, Philip, Kitron, U., Elder, J. P., Halsey, E. S., Morrison, A. C., Kochel, T. J. and Scott, T. W. (2014) 'Time-varying, serotype-specific force of infection of dengue virus'. Proceedings of the National Academy of Sciences, Vol 111, Issue 26, E2694-E2702.
- Traoré S, Wilson MD, Sima A, Barro T, Diallo A, Aké A, Coulibaly S, Cheke RA, Meyer RRF, Mas J, McCall PJ, Post RJ, Zouré H, Noma M, Yaméogo L, Sékétéli AV & Amazigo UV. (2009) The elimination of the onchocerciasis vector from the island of Bioko as a result of larviciding by the WHO African Programme for Onchocerciasis Control. Acta Tropica, 111, 211-8.
- Kisinza WN, Talbert A, Mutalemwa P & McCall PJ (2008) Community knowledge, attitudes and practices related to tick-borne relapsing fever in Dodoma Rural District, Central Tanzania. Tanzania Journal of Health Research, 10, 131-136.
- Rajatileka S, Black WC, Saavedra-Rodriguez K, Trongtokit Y, Apiwathnasorn C, McCall PJ & Ranson H. (2008) Development and application of a simple colorimetric assay reveals widespread distribution of sodium channel mutations in Thai populations of Aedes aegypti. Acta Tropica, 108, 54-7.
- Lenhart A, Orelus N, Maskill R, Alexander N, Streit T & McCall PJ. (2008) Insecticide treated bednets to control dengue vectors: preliminary evidence from a controlled trial in Haiti. Tropical Medicine & International Health, 13(1), 56-67.
- McCall PJ, Hume J, Motshegwa K, Pignatelli P, Talbert A & Kisinza W. (2007) Does TBRF have an animal reservoir in East Africa? Vector Borne & Zoonotic Diseases,7, 659-666. DOI: 10.1089/vbz.2007.0151.
- Mzilahowa T, McCall PJ & Hastings I. (2007) "Sexual" population structure and genetics of the malaria agent P. falciparum. PLoS One, http://www.plosone.org/doi/pone.0000613
- Wacira DG, Hill J, McCall PJ & Kroeger A. (2007) The delivery of Insecticide Treated Net (ITN) services through employer and community based approaches in Kenya. Tropical Medicine & International Health, 12, 140-149.
- Kroeger A, Lenhart AE, Ochoa M, Villegas E, Levy M, Alexander N & McCall, PJ. (2006) Effective dengue vector control with curtains and water container covers treated with insecticide in Mexico and Venezuela: cluster randomised trials. BMJ, 332, 1247-1250.
- Abe M, McCall PJ, Lenhart A, Villegas E, & Kroeger A. (2005) The Buen Pastor cemetery in Trujillo, Venezuela: measuring dengue vector output from a public area. Tropical Medicine & International Health, 10, 597-603.
- Klinkenberg E., McCall PJ, Wilson MD, Amerasinghe F & Donnelly MJ. (2005) High malaria prevalence and urban agriculture in Accra, Ghana. Emerging Infectious Disease, 11, 1290-1293.
- Kisinza W, McCall PJ, Mitani H, Talbert A & Fukunaga M. (2003) A newly identified tick-borne Borrelia species and relapsing fever in Tanzania. The Lancet, 362, 1283-1284.
Reviews, editorials, commentaries and book chapters.
- McCall PJ, Lloyd L. & Nathan MB (2009) Vector management and delivery of vector control services Chapter 3 in Dengue Guidelines for diagnosis, treatment, prevention and control 3rd edition. WHO.
- McCall PJ & Lenhart A. (2008) Dengue control. The Lancet Infectious Diseases, 8(1), 7-9.
- McCall PJ & Kittayapong K. (2007) Control of dengue vectors: tools and strategies. Report of the Scientific Working Group meeting on Dengue, Geneva, 1-5 October 2006. pp. 110-119. http://www.who.int/tdr/publications/publications/swg_dengue_2.htm
- Farrar J, Focks D, Gubler D, Barrera R, Guzman MG, Simmons C, Kalayanarooj S, Lum L, McCall PJ, Lloyd L, Nathan M, Kroeger A, on behalf of the WHO/TDR Dengue Scientific Working Group. (2007) Editorial: Towards a global dengue research agenda. Tropical Medicine & International Health, 12, 695-699.