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Staff Profile: Anja (Dianne) Terlouw

Anja TerlouwAnja (Dianne) Terlouw, MD PhD

Appointment: Clinical Epidemiologist/ Clinical Lecturer
Areas of interest:
Malaria epidemiology in pregnancy and childhood.

Background
Anja Terlouw is a Dutch clinical epidemiologist trained at the University of Amsterdam (MD and PhD) and the Erasmus University in Rotterdam (MSc, clinical epidemiology). She previously worked at the CDC/KEMRI research unit in western Kenya on community-based studies on the epidemiology, treatment and prevention of malaria (1997-2001). Following this, she worked with the Malaria Epidemiology Branch at CDC in Atlanta for one year, before finishing her education in Holland. She joined the malaria epidemiology unit of the School in early 2004 to continue with operational research linked to the control of malaria.

Teaching
Lectures on the basics of epidemiology and malaria epidemiology at post-graduate Masters and Diploma Courses at LSTM. Supervision of MSc and PhD students.
Research
Research interests include operational research linked to the burden, prevention, and treatment of malaria in pregnant women and children, and the development of antimalarial dose regimens based on age.

Students
Rukhsana Ahmed. (Part time: 2005 - ) Malaria in pregnancy studies. Malaria Research Council, Jabalpur, Madhya Pradesh, India.

Daniel Hayes. (Part time: 2006 - ) Development of age and height based dosing regimens for antimalarials as alternatives to weight-based dose regimens, LSTM.

Katharine Winter. (2009 - ) PK-PD modelling antimalarials, LSTM

Queen Dube. (2009 - ) Neonatal Sepsis, aetiology and long-term outcome, Malawi.

Current projects and grants

Modelling:  Age and weight-based dose regimens for the fixed-dose combination of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Asia, Africa and Latin America
Funding - European & Developing Countries Clinical Trials Partnership (EDCTP)
2009 - present. Role: PI and grant holder

Cluster-randomized cohort study to assess the safety and effectiveness of combination therapies in repeated treatments for uncomplicated P. falciparum malaria over a three-year period.
Funding - Bill & Melinda Gates Foundation
2008 - present.  Role:Co-PI and shared grant holder

Modelling: Development of age and weight based dose regimens for a new fixed-doseartesunate-mefloquine combination for uncomplicated falciparum malaria.
Funding -Drugs for Neglected Diseases initiative (DNDi)
2008- present. PI and Grant holder

Institutional collaboration between LSTM and Centers for Disease Control Prevention (CDC) over a five year period- Technical assistance/collaborative research on malaria
Funding - Centers for Disease Control and Prevention
2005 - present.  Role: Co-Investigator

Research grants

See above.

Other relevant expertise, professional memberships etc.

Professional Memberships:
Royal Society of Tropical Medicine and Hygiene (UK)
American society for Tropical Medicine and Hygiene (USA)

Other:
Member Liverpool Associates in Tropical Health (LATH) malaria advisory board
Member RBM Malaria Monitoring and Evaluation Reference Group (MERG)
Member Data Safety Monitoring Board (DSMB) multi-country, multi centre RCT
Member Liverpool School of Tropical Medicine Research Ethics Committee
Member Liverpool School of Tropical Medicine Governance Oversight Committee
Member Liverpool School of Tropical Medicine Data Management Working Group


Recent Publications

Jump to: Article
Number of items: 29.

Kariuki, Simon K, Njung'e, James, Muia, Ann, Muluvi, Geofrey, Gatei, Wangeci, Ter Kuile, Feiko, Terlouw, Dianne J, Hawley, William A, Phillips-Howard, Penelope, Nahlen, Bernard L, Lindblade, Kim A, Slutsker, Laurence and Shi, Ya Ping (2013) 'Effect of malaria transmission reduction by insecticide-treated bed nets (ITNs) on the genetic diversity of Plasmodium falciparum merozoite surface protein (MSP-1) and circumsporozoite (CSP) in western Kenya'. Malaria Journal, Vol 12, Issue 295.

Davies, Emma C., Chandler, Clare I. R., Innocent, Simeon H., Kalumuna, Charles, Terlouw, Dianne J., Lalloo, David G., Staedke, Sarah G. and Haaland, Ane (2012) 'Designing Adverse Event Forms for Real-World Reporting: Participatory Research in Uganda'. PLoS ONE, Vol 7, Issue 3, e32704.

Roca-Feltrer , Arantxa, Lalloo, David G., Phiri, Kamija and Terlouw, Dianne J. (2012) 'Rolling Malaria Indicator Surveys (rMIS): a potential district-level malaria monitoring and evaluation (M&E) tool for programme managers'. American Journal of Tropical Medicine and Hygiene, Vol 86, Issue 1, pp. 96-98.

Hill, Helen, Baines, Paul, Barton, Paul, Newland, Paul, Terlouw, Anja and Turner, Mark (2011) 'Uncertainties in the measurement of blood glucose in paediatric intensive care: implications for clinical trials of tight glycaemic control'. Intensive Care Medicine, Vol 37, Issue 9, pp. 1517-1524.

Gatei, Wangeci, Kariuki, Simon, Hawley, William, Ter Kuile, Feiko, Terlouw, Anja, Phillips-Howard, Penelope, Nahlen, Bernard, Gimnig, John, Lindblade, Kim, Walker, Edward, Hamel, Mary, Crawford, Sara, Williamson, John, Slutsker, Laurence and Shi, Ya Ping (2010) 'Effects of transmission reduction by insecticide-treated bed nets (ITNs) on parasite genetics population structure: I. The genetic diversity of Plasmodium falciparum parasites by microsatellite markers in western Kenya.'. Malaria journal, Vol 9, Issue 353.

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Selected Publications

  1. van Buuren S, Hayes DJ, Stasinopoulos DM, Rigby RA, ter Kuile FO, and Terlouw DJ. Estimating regional centile curves from mixed data sources and countries. Statistics in Medicine 2009. 28; 23: 2891-911.
  2. Larru B, Molyneux E, ter Kuile FO, Taylor T, Molyneux M, Terlouw DJ. Malaria in young infants: Retrospective surveillance of hospital admission records in Blantyre, Malawi. Malaria Journal 2009;8(1):310.
  3. Vanden Eng JL, Wolkon A, Frolov AS, Terlouw DJ , Eliades MJ, Morgah K, Takpa V, Dare A, Sodahlon YK, Doumanou Y, Hawley WA, Hightower AW. Use of handheld computers with global positioning system for probability sampling and data entry in household surveys. AJTMH 2007;77:393-399.
  4. Eliades MJ, Morgah K, Wolkon A, Crawford SB, Hawley WA, Hightower AW, ter Kuile FO, and Terlouw DJ. Burden of malaria at community level in children less than 5 years of age in Togo. AJTMH 2006. 75; 4: 622-629.
  5. Taylor WR, Terlouw DJ, Olliaro PL, White NJ, Brasseur P, ter Kuile FO. Use of weight- for-age data to optimize tablet strength and dosing regimens for new fixed-dose combination of artesunate-amodiaquine for treating falciparum malaria. Bull WHO 2006;84:956-964.