Staff Profile: Anja (Dianne) Terlouw
Anja (Dianne) Terlouw, MD PhD
Appointment: Clinical Epidemiologist/ Clinical Lecturer
Areas of interest: Malaria epidemiology in pregnancy and childhood.
Anja Terlouw is a Dutch clinical epidemiologist trained at the University of Amsterdam (MD and PhD) and the Erasmus University in Rotterdam (MSc, clinical epidemiology). She previously worked at the CDC/KEMRI research unit in western Kenya on community-based studies on the epidemiology, treatment and prevention of malaria (1997-2001). Following this, she worked with the Malaria Epidemiology Branch at CDC in Atlanta for one year, before finishing her education in Holland. She joined the malaria epidemiology unit of the School in early 2004 to continue with operational research linked to the control of malaria.
Lectures on the basics of epidemiology and malaria epidemiology at post-graduate Masters and Diploma Courses at LSTM. Supervision of MSc and PhD students.
Research interests include operational research linked to the burden, prevention, and treatment of malaria in pregnant women and children, and the development of antimalarial dose regimens based on age.
Rukhsana Ahmed. (Part time: 2005 - ) Malaria in pregnancy studies. Malaria Research Council, Jabalpur, Madhya Pradesh, India.
Daniel Hayes. (Part time: 2006 - ) Development of age and height based dosing regimens for antimalarials as alternatives to weight-based dose regimens, LSTM.
Katharine Winter. (2009 - ) PK-PD modelling antimalarials, LSTM
Queen Dube. (2009 - ) Neonatal Sepsis, aetiology and long-term outcome, Malawi.
Current projects and grants
Modelling: Age and weight-based dose regimens for the fixed-dose combination of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Asia, Africa and Latin America
Funding - European & Developing Countries Clinical Trials Partnership (EDCTP)
2009 - present. Role: PI and grant holder
Cluster-randomized cohort study to assess the safety and effectiveness of combination therapies in repeated treatments for uncomplicated P. falciparum malaria over a three-year period.
Funding - Bill & Melinda Gates Foundation
2008 - present. Role:Co-PI and shared grant holder
Modelling: Development of age and weight based dose regimens for a new fixed-doseartesunate-mefloquine combination for uncomplicated falciparum malaria.
Funding -Drugs for Neglected Diseases initiative (DNDi)
2008- present. PI and Grant holder
Institutional collaboration between LSTM and Centers for Disease Control Prevention (CDC) over a five year period- Technical assistance/collaborative research on malaria
Funding - Centers for Disease Control and Prevention
2005 - present. Role: Co-Investigator
Other relevant expertise, professional memberships etc.
Royal Society of Tropical Medicine and Hygiene (UK)
American society for Tropical Medicine and Hygiene (USA)
Member Liverpool Associates in Tropical Health (LATH) malaria advisory board
Member RBM Malaria Monitoring and Evaluation Reference Group (MERG)
Member Data Safety Monitoring Board (DSMB) multi-country, multi centre RCT
Member Liverpool School of Tropical Medicine Research Ethics Committee
Member Liverpool School of Tropical Medicine Governance Oversight Committee
Member Liverpool School of Tropical Medicine Data Management Working Group
Ewing, Victoria L., Terlouw, Anja, Kapinda, Andrew, Pace, Cheryl, Richards, Esther, Tolhurst, Rachel and Lalloo, David (2015) 'Perceptions and utilization of the anti-malarials artemether-lumefantrine and dihydroartemisinin-piperaquine in young children in the Chikhwawa District of Malawi: a mixed methods study'. Malaria Journal, Vol 14, e13. (In Press)
Ramos Martin, Virginia, Gonzalez-Martinez, Carmen, Mackenzie, Ian, Schmutzhard, Joachim, Pace, Cheryl, Lalloo, David and Terlouw, Anja (2014) 'Neuroauditory Toxicity of Artemisinin Combination Therapies—Have Safety Concerns Been Addressed?'. American Journal of Tropical Medicine and Hygiene, Vol 91, Issue 1, pp. 62-73.
Ocholla, Harold, Preston, Mark D, Mipando, Mwapatsa, Jensen, Anja Tr, Campino, Susana, MacInnis, Bronwyn, Alcock, Daniel, Terlouw, Anja, Zongo, Issaka, Oudraogo, Jean-Bosco, Djimde, Abdoulaye A, Assefa, Samuel, Doumbo, Ogobara K, Borrmann, Steffen, Nzila, Alexis, Marsh, Kevin, Fairhurst, Rick M, Nosten, Francois, Anderson, Tim Jc, Kwiatkowski, Dominic P, Craig, Alister, Clark, Taane G and Montgomery, Jacqui (2014) 'Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates'. The Journal of Infectious Diseases, Vol 210, Issue 12, pp. 1991-2000.
Ahmed, Rukhsana, Singh, Neeru, Ter Kuile, Feiko, Bharti, Praveen K, Singh, Pushpenda P, Desai, Meghna, Udhayakumar, Venkatachalam and Terlouw, Anja (2014) 'Placental infections with histologically confirmed Plasmodium falciparum are associated with adverse birth outcomes in India: a cross-sectional study'. Malaria Journal, Vol 13, :232.
Hodel, Eva Maria, Kay, Katherine, Hayes, Daniel J., Terlouw, Anja and Hastings, Ian (2014) 'Optimizing the programmatic deployment of the anti-malarials artemether-lumefantrine and dihydroartemisinin-piperaquine using pharmacological modelling'. Malaria Journal, Vol 13, e138.
- van Buuren S, Hayes DJ, Stasinopoulos DM, Rigby RA, ter Kuile FO, and Terlouw DJ. Estimating regional centile curves from mixed data sources and countries. Statistics in Medicine 2009. 28; 23: 2891-911.
- Larru B, Molyneux E, ter Kuile FO, Taylor T, Molyneux M, Terlouw DJ. Malaria in young infants: Retrospective surveillance of hospital admission records in Blantyre, Malawi. Malaria Journal 2009;8(1):310.
- Vanden Eng JL, Wolkon A, Frolov AS, Terlouw DJ , Eliades MJ, Morgah K, Takpa V, Dare A, Sodahlon YK, Doumanou Y, Hawley WA, Hightower AW. Use of handheld computers with global positioning system for probability sampling and data entry in household surveys. AJTMH 2007;77:393-399.
- Eliades MJ, Morgah K, Wolkon A, Crawford SB, Hawley WA, Hightower AW, ter Kuile FO, and Terlouw DJ. Burden of malaria at community level in children less than 5 years of age in Togo. AJTMH 2006. 75; 4: 622-629.
- Taylor WR, Terlouw DJ, Olliaro PL, White NJ, Brasseur P, ter Kuile FO. Use of weight- for-age data to optimize tablet strength and dosing regimens for new fixed-dose combination of artesunate-amodiaquine for treating falciparum malaria. Bull WHO 2006;84:956-964.