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Staff Profile: Robert S Heyderman
Robert S Heyderman PhD FRCP DTM&H
Professor of Tropical Medicine,
Director, Malawi-Liverpool-Wellcome Trust, Clinical Research Programme
Curent Research
- Endothelial biology & coagulopathy of severe infection
- Mucosal immunity
- Development of naturally acquired immunity to Neisseria meningitidis & Streptococcus pneumoniae
- Regulation of the host inflammatory response
- Clinical diagnosis and management of meningitis and septicaemia
Present Co-workers in Malawi
Queen Dube (Paediatrician)
Sarah Glennie (Post-Doctoral Scientist)
Wilson Mandala (Lecturer, CoM)
Chris Moxon (Wellcome Trust Clinical PhD Fellow)
Jamie Raylance (Wellcome Trust Clinical PhD Fellow)
Kondwani Jambo (PhD Student)
Enoch Sepako (Phd Student)
Darmie Unuigbe (PhD Student)
Toney Nyirenda (Wellcome Trust Masters Student)
Other Research Interests
- Bacterial pathogenesis
- Infectious disease epidemiology
- TB Diagnosis
- Influenza Surveillance in Africa
Recent Publications
Glennie, Sarah J., Sepako, Enoch, Mzinza, David, Harawa, Visopo, Miles, David J.C., Jambo, Kondwani C., Gordon, Stephen, Williams, Neil A and Heyderman, Robert (2011) 'Impaired CD4 T Cell Memory Response to Streptococcus pneumoniae Precedes CD4 T Cell Depletion in HIV-Infected Malawian Adults'. PLos ONE, Vol 6, Issue 9, pp. 1-10.
Waitt, Catriona, Banda, N. Peter K., White, Sarah A., Kampmann, Beate, Kumwenda, Jean, Heyderman, Robert, Pirmohamed, Munir and Squire, Bertie (2011) 'Early Deaths During Tuberculosis Treatment Are Associated With Depressed Innate Responses,Bacterial Infection, and Tuberculosis Progression'. Journal of Infectious Diseases, Vol 2011, Issue 204, pp. 358-362.
Jambo, Kondwani C., Sepako, Enoch, Fullerton, Duncan, Mzinza, David, Glennie, Sarah, Wright, Adam K., Heyderman, Robert and Gordon, Stephen (2011) 'Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults'. Thorax, Vol 66, pp. 375-382.
Gordon, Melita A, Kankwatira, Anstead M K, Mwafulirwa, Gershom, Walsh, Amada L, Hopkins, Mark J, Parry, Christopher M, Faragher, Brian, Zijlstra, Eduard E, Heyderman, Robert and Molyneux, Malcolm E (2010) 'Invasive Non-typhoid Salmonellae Establish Systemic Intracellular Infection in HIV-Infected Adults: An Emerging Disease Pathogenesis'. Clinical Infectious Diseases, Vol 50, Issue 7, pp. 953-962.
Moxon, C. A., Heyderman, Robert and Wassmer, Samuel (2009) 'Dysregulation of coagulation in cerebral malaria'. Molecular and Biochemical Parasitology, Vol 166, Issue 2, pp. 99-108.
Selected Publications
Jambo KC, Sepako E, Heyderman RS, Gordon SB. Potential role for mucosally active vaccines against pneumococcal pneumonia. Trends Microbiol. In press.
Chaplow R, Palmer B, Heyderman R, Moppett J, Marks DI. Stenotrophomonas maltophilia bacteraemia in 40 haematology patients: risk factors, therapy and outcome. Bone Marrow Transplant. In press
Miles DJC, Gadama L, Gumbi A, Nyalo F, Makanani B, Heyderman RS. HIV infection during pregnancy induces CD4 T-cell differentiation and modulates responses to BCG vaccine in HIV-uninfected infants.Immunology In press
Kingsley RA, Msefula CL, Thomson NR, Kariuki S, Holt KE, Gordon MA, Harris D, Clarke L, Whitehead S, Sangal V, Marsh K, Achtman M, Molyneux ME, Cormican M, Parkhill J, MacLennan CA, Heyderman RS, Dougan G. Epidemic multiple drug resistant Salmonella Typhimurium causing invasive disease in sub-Saharan Africa have a distinct genotype. Genome Res. 2009;19:2279-2287.
Carrol ED, Mankhambo LA, Jeffers G, Parker D, Guiver M, Newland P, Banda DL, Molyneux EM, Heyderman RS, Molyneux ME, Hart CA. The diagnostic and prognostic accuracy of five markers of serious bacterial infection in Malawian children with signs of severe infection. PLoS One. 2009;4:e6621.
Mureithi MW, Finn A, Ota MO, Zhang Q, Davenport V, Mitchell TJ, Williams NA, Adegbola RA, Heyderman RS. T Cell Memory Response to Pneumococcal Protein Antigens in an Area of High Pneumococcal Carriage and Disease. J Infect Dis 2009;200:783-93.
Russell DG, VanderVen B, Glennie S, Mwandumba H, Heyderman RS. The macrophage marches on its phagosome: dynamic assays of phagosome function. Nat Rev Immunol 2009;9: 594-600.
Horton RE, Vidarsson G, Virji M, Williams NA, Heyderman RS. IgA1 antibodies specific for outer membrane protein PorA modulate the interaction between Neisseria meningitidis and the epithelium. Microb Pathog 2009;46:253-60.
Morales-Aza B, Glennie SJ, Garcez TP, Davenport V, Johnston SL, Williams NA, Heyderman RS. B cells maintain naturally acquired T cell memory following bacterial colonization. Blood 2009;113:4206-4212
Vaughan AT, Gorringe A, Davenport V, Williams NA, Heyderman RS. Evasion of Mucosal Immunity in the Human Upper Respiratory Tract by the Commensal Bacteria Neisseria lactamica but not Pathogenic Neisseria meningitidis. J Immunol 2009;182:2231-2240
Geretti AM, Brook G, Cameron C, Chadwick D, Heyderman RS, MacMahon E, Pozniak A, Ramsay M, Schuhwerk M. British HIV Association guidelines for immunization of HIV-infected adults 2008. HIV Med. 2008;9:795-848
Davenport V, Groves E, Horton RE, Hobbs CCG, Guthrie T, Findlow J, Borrow R, Næss LM, Oster P, Heyderman RS, Williams NA. Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B. J Infect Dis. 2008;198:731-740.
Hobbs, C.G., Groves, E., Davenport, V., Bailey, M., Williams, N.A., Birchall, M.A., and Heyderman, R.S. 2007. Tonsil T cell Immunity to Human Papillomavirus in the Absence of Detectable Virus in Healthy Adults. Laryngoscope 2008;118:459-463.
Davenport V, Groves E, Hobbs CCG, Williams NA, Heyderman RS. Regulation of Th-1 T cell dominated immunity to Neisseria meningitidis within the human mucosa Cell Microbiol 2007;9:1050-1061.
Griffiths NJ, Bradley CJ, Heyderman RS, Virji M. IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1. Cell Microbiol. 2007;9:2968-83.
